DAYBUE is a ready-to-take liquid

Your doctor will determine the appropriate amount of medication based on your loved one's weight. Always follow the instructions of your doctor and pharmacist when preparing DAYBUE.

What to know about taking DAYBUE

DAYBUE may be given orally or via a gastrostomy (G) tube. If your loved one has a gastrojejunal (GJ) tube, it must be given through the G-port
DAYBUE is strawberry-flavored, taken twice daily, once in the morning and once again in the evening, and can be taken with or without food
If your loved one misses a dose, skip that dose and take the next dose at the usual time. Do not take 2 doses to make up the missed dose
If your loved one vomits after taking a dose, do not give another dose to make up for that dose. Wait and give the next dose at the next scheduled time. Call your doctor if vomiting does not stop

Tips for managing side effects

The DAYBUE Starting Treatment Discussion Guide for caregivers, a tool you can use to talk to your child's doctor about DAYBUE

This guide can help you and your loved one prepare for and get the most out of treatment.

Download Getting Started Guide

Helpful tips for giving DAYBUE by mouth

Use something cold to numb the tastebuds like ice cream, an ice cube, or cold water before giving DAYBUE
Dip your medication syringe in sweet syrup* and gently squirt DAYBUE into the side of your loved one's cheek. Do not squirt into the back of the throat, as this could cause choking
Use play to help increase your loved one's involvement in taking DAYBUE, like pretending to give medicine to a favorite toy
Give a strong-tasting food or drink afterwards to help remove the taste
When you are done, consider giving your loved one a reward, like playing a favorite game

*DAYBUE oral solution should not be mixed directly with any sweetener.

Use the DAYBUE^® Daily Treatment Journal to help you identify small changes that may impact daily life and help you and your care team stay informed.

Download now

How will I receive DAYBUE?

Your DAYBUE prescription will be filled by a specialty pharmacy.

We partner with AnovoRx, a specialty pharmacy that focuses on medications that have special handling, storage, and delivery requirements, like DAYBUE. Once your loved one's prescription details are finalized, they will schedule delivery to the location you specify. Acadia Connect will reach out to you regularly to coordinate shipping refills.

Each month you will receive a refrigerated box containing:

6 or 8 bottles of DAYBUE depending on your loved one’s weight-based dose
2 oral syringes and 2 Press-In Bottle Adapters (PIBA)

Once you’ve received your shipment:

Store DAYBUE in a refrigerator at a temperature between 36°F to 46°F (2°C to 8°C)

Do not freeze

Always store DAYBUE in an upright position

Keep the child-resistant cap tightly closed

Discard any unused DAYBUE after 14 days of opening the bottle

Keep DAYBUE and all medicines out of the reach of children

AnovoRx Specialty Pharmacy

AnovoRx will process and fill DAYBUE prescriptions and have clinical pharmacists available 24/7 to:

Answer questions and offer treatment support for DAYBUE
Provide information about potential side effects
Offer clinical recommendations (when appropriate)

Questions about delivery?

Contact Acadia Connect for support at 1-844-737-2223, Monday–Friday, 8:00AM to 8:00PM ET.

DAYBUE Packaging Materials Recycle Program

We are pleased to offer a recycling service to help you dispose of the DAYBUE packaging materials that come with your medicine. This program is a prepaid service sponsored by Acadia Pharmaceuticals Inc. There is no additional cost to you.

The recycling service is only available in the United States, excluding Alaska, Hawaii, and US territories.

Learn more about the recycling program

Indication and Important Safety Information

What is DAYBUE or DAYBUE STIX (trofinetide)?

DAYBUE or DAYBUE STIX are prescription medicines used to treat Rett syndrome in adults and children 2 years of age and older. It is not known if DAYBUE or DAYBUE STIX is safe and effective in children under 2 years of age.

What are the possible side effects of DAYBUE or DAYBUE STIX?

Diarrhea: Diarrhea is a common side effect of DAYBUE or DAYBUE STIX that can sometimes be severe. Diarrhea may cause you to lose too much water from your body (dehydration). Before starting treatment with DAYBUE or DAYBUE STIX, stop taking laxatives. Tell your healthcare provider if you have diarrhea while taking DAYBUE or DAYBUE STIX. Your healthcare provider may ask you to increase the amount you drink or take antidiarrheal medicine as needed.
Vomiting: Vomiting is a common side effect of DAYBUE or DAYBUE STIX. Sometimes vomit can get into your lungs (aspiration), which could cause an infection (aspiration pneumonia). Tell your healthcare provider if you have severe vomiting or if vomiting happens often.
Weight loss: DAYBUE or DAYBUE STIX can cause weight loss. Tell your healthcare provider if you notice you are losing weight at any time during treatment with DAYBUE or DAYBUE STIX.
The most common side effects of DAYBUE or DAYBUE STIX include diarrhea and vomiting. Other side effects include fever, seizure, anxiety, decreased appetite, tiredness, and the common cold. These are not all the possible side effects of DAYBUE or DAYBUE STIX. Tell your healthcare provider if you have any side effects that bother you or do not go away.

What should I tell my healthcare provider before taking DAYBUE or DAYBUE STIX?

Before taking DAYBUE or DAYBUE STIX, tell your healthcare provider about all of your medical conditions, including if you:

have kidney problems.
are pregnant or plan to become pregnant. It is not known if DAYBUE or DAYBUE STIX will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if DAYBUE or DAYBUE STIX passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking DAYBUE or DAYBUE STIX.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking DAYBUE or DAYBUE STIX with certain medicines may affect how the other medicines work and can cause serious side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You can also call Acadia Pharmaceuticals Inc. at 1-844-4ACADIA (1-844-422-2342).

DAYBUE is available as an oral solution (200 mg/mL).

DAYBUE STIX for oral solution powder is available in 5,000 mg, 6,000 mg, and 8,000 mg packets.

The risk information provided here is not comprehensive. To learn more, talk with your healthcare provider and read the full Prescribing Information, including Patient Information, also available at DAYBUE.com.