Managing side
effects

Ellie, age 15, living with Rett syndrome, with her parentsEllie, age 15, living with Rett syndrome, with her parents mobile

Madelyn, age 5, on DAYBUE® since 2023, with her mom

Helpful tips to consider for managing diarrhea

If you are accustomed to treating for constipation, managing diarrhea may be new to you. Diarrhea did occur in some individuals taking DAYBUE who previously experienced constipation.

Before your loved one starts treatment, talk to your doctor about a management plan to address the possible side effect of diarrhea while on treatment with DAYBUE or DAYBUE® STIX.

Before your loved one starts treatment with DAYBUE or DAYBUE STIX:

  • Consider keeping a log to track stool consistency/frequency for 1 week before starting treatment

  • Tell your doctor if you are giving your loved one stool softeners and other medicines or dietary supplements for the treatment of constipation

  • Stop use of laxatives

  • Talk to your doctor about any recommended dietary changes, including potential use of supplemental fiber

Starting DAYBUE or DAYBUE STIX if diarrhea is a concern:

  • Based on your doctor's clinical judgement and experience, they may decide to start with a lower dose and increase to the FDA-recommended weight-based dose over time

  • Improvements may not occur until your loved one reaches the recommended dose and continues treatment

  • The impact of this approach on diarrhea was evaluated in LAVENDER™. Individual patient response may vary

The LAVENDER study findings were based on starting patients at the FDA-recommended weight-based dose of DAYBUE and continuing treatment for 12 weeks.

Take steps to plan ahead

This might include stocking up on supplies like wipes, chucks, and extra diapers, or creating a backup bag with a change of clothes for when you’re away from home.

Helpful tip before treatment begins

Letting your loved one’s school or other members of the care team know about possible treatment effects is a great step to take before starting DAYBUE or DAYBUE STIX.

If diarrhea occurs*:

  • Tell your doctor if your loved one has diarrhea

  • Keep an eye on your loved one’s fluid intake and watch for signs of dehydration; increase oral fluids, if needed. Your doctor may also suggest a fiber supplement, if appropriate

  • It is recommended that you have antidiarrheal medications at home so you can manage diarrhea as needed

  • Your doctor may reduce the dose of DAYBUE or DAYBUE STIX or may ask you to stop treatment until diarrhea improves. Do not stop treatment before talking to your doctor

Tips for managing vomiting*:

  • Vomiting and swallowing can be issues for individuals with Rett syndrome. Talk to your doctor about ways to manage vomiting before starting DAYBUE or DAYBUE STIX

  • Have meals somewhere calm. Your loved one’s stomach can be sensitive to stress. Finding somewhere relaxed to eat can reduce the likelihood of vomiting

  • Avoid meals before bedtime or nap time

  • Keep a meal journal. A journal can help you track connections between certain foods and vomiting. By removing foods one-by-one you can figure out if a particular food is causing vomiting

*This is not a complete list of the ways to manage diarrhea and vomiting. Talk to your doctor about making a plan that is tailored to your loved one’s unique needs.

Clare, age 9, on DAYBUE since 2021Clare, age 9, on DAYBUE since 2021

Clare, age 9, on DAYBUE since 2021

Tell your doctor about all of the medicines your loved one takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking DAYBUE or DAYBUE STIX with certain medicines may affect how the other medicines work and can cause serious side effects.

Clare, age 9, on DAYBUE since 2021

DAYBUEDAYBUE STIX